The present investigation was aimed to formulate transdermal films incorporating herbal Drug components. The allopathic system of medicine includes two conventional lines of treatment for rheumatoid arthritis, which come along with certain side effects. Hence, turning to safe, effective and time-tested Ayurvedic herbal drug formulation would be a preferable option.With this view transdermal films incorporating herbal drug cloroform extract of Trichodesma indicum and Boswellia serrata was envisaged. The drugs were selected on the basis that they produce synergistic action in suppressing inflammation and are proved time tested and safe drug. Chloroform extract of trichodesma indicum and Boswellia serrata are dissolved in chloroform and dispersed uniformly throughout the film. The film of chloroform extract of trichodesma indicm and Boswellia serrata showed a satisfactory flatness in 99.0 % and Average thickness of films was found to be 0.0085 cm . Average content of chloroform extract of trichodesma indicm and Boswellia serrata in films was found to be 78.91% and 88.72% respectively. The calibration curve of chloroform extract of trichodesma indicm and Boswellia serrata was prepared in hydroalcoholic medium using HPTLC and UV. The polymeric films were evaluated for their physical properties like percentage flatness, thickness uniformity, and drug content and diffusion studies across hairless mouse skin. The average per cent release of trichodesma indicum extract was found to be 48.70% and 69.84% for Boswellia serrata in the hydroalcoholic diffusion medium at the end of 9 hrs. The graphs obtained for the average per cent release through transdermal film indicate drug release occurred at a constant rate.The skin irritation study done on albino rabbit skin showed that the formulation does not produce irritation to the skin.Overall, it was observed that the herbal drugs have been found to be effective through modern pharmaceutical formulation techniques.
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